Thank you for your interest in participating in this survey!
Purpose of the Survey
The goal of this survey is to map allergic reactions to excipients commonly used in drugs.
Time Commitment
Completing this survey will take approximately 30 minutes. You can save your progress at any time by clicking on "resume later" and return to finish the survey later.
Opportunity for Co-Authorship
By completing the entire questionnaire, you have the option to be listed as a co-author in an eventual publication. If you are interested, you can provide your contact details later in the survey. Only one co-author per center can be included for adult and paediatric cases, respectively (see important information below).
Important Information
Please read the following carefully before starting the survey:
One respondent per centre
In order to exclude duplicate responses and data, each centre is limited to one respondent for adult and one respondent for paedriatric cases. Only these respondents will be considered as potential co-authors and should compile and input all data for their centre. In case multiple specialists submit cases from the same centre, we will ask you to clarify potential overlap and decide internally for co-authorship.
If you would prefer to circulate this survey within your centre before entering your data, you have the option to download the provided Word file.”
Definition of excipients
In this survey, excipients are defined as all agents added to drug formulations other than the active substance.
Based on literature and experience, the following (non-exhaustive) list of excipients contains the most well-described potential culprits of allergic hypersensitivity reactions: polyethylene glycols (PEG) or macrogols), polysorbates or Tween (incl. polysorbate 80 or E433, polysorbate 20 or E432), poloxamers, methylcelluloses (incl. carboxymethylcellulose or E466, hydroxypropylmethylcellulose or E464), gelatines (E441), mannitol (E421) and povidone (polyvinylpyrrolidone, E1201).
Definition of excipient allergy
In this survey, excipient allergy is defined as a combination of:
- A clinical history of type I immediate (IgE-mediated) or type IV delayed (T cell-mediated) hypersensitivity to one or more systemically administered drugs containing a common excipient
and
- Allergy testing (e.g. skin testing, provocation testing, in vitro and/or ex vivo testing) demonstrating with a high degree of certainty that the excipient and not the active ingredient was the most likely cause of the reaction(s).
